Chem/Bio/Light/Pressure Sensors become an indispensable part of our lives due to development of technology. These sensors detect chemicals, light, and physical stress. Especially, transistor sensors could amplify the detection signal by controlling their gate voltage or drain voltage (Vgs and Vds). And also organic materials based sensors have the advantage of being light weight, flexible, easy to fabrication using solution process, and controllable properties by molecular design. Especially we reported a new method of direct detection of liquid phase analysis with side-chain engineering. Organic materials based sensors have the potential by tuning molecular structure or geometric structure.